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Chronic High Doses of Cannabinoids Promote Hippocampal Neurogenesis
Bryan Perkins / June 20, 2009

“The recent discovery that the hippocampus is able to generate new neurons throughout a human’s lifespan has changed the way we think about the mechanisms of psychiatric disorders and drug addiction,” says Wen Jian and colleagues in a study published in the Journal of Clinical Investigation in 2005. It appears that cannabinoids are able to modulate pain, nausea, vomiting, epilepsy, ischemic stroke, cerebral trauma, multiple sclerosis, tumors, and many other disorders. Cannabinoids act on two types of receptors, the CB1 receptors (found mainly in the brain) and the CB2 receptors (found mainly in the immune system). The CB1 receptor is one of the most abundant G protein coupled receptors in the mammalian brain and it accounts for most, if not all, of the centrally mediated effects of cannabinoids. Cannabionoid receptors are evolutionarily conserved amoung various vertebrates and invertebrates which have been separate for 500 million years.

Hippocampal neurogenesis is suppressed following chronic administration of the major drugs of abuse (including opiates, alcohol, nicotine, and cocaine). However, CB1-knockout mice display significantly decreased hippocampal neurogenesis, suggesting that CB1 receptors activated by endogenous, plant-derived, or synthetic cannabinoids may promote hippocampal neurogenesis.

Wen Jiang and colleagues have given the first evidence suggesting that both embryonic and adult hippocampal neural stem/progenitor cells (NS/PCs) express CB1 receptors. Cannabinoids can regulate the proliferation of hippocampal NS/PCs by acting on CB1 receptors. They found that both the synthetic cannabinoid HU210 and the endocannabinoid anandamide profoundly promote embryonic hippocampal NS/PC proliferation.

Chronic, but not acute, HU210 significantly increases the number of newborn hippocampal neurons in adult rats by promoting NS/PC proliferation. These promoting effects are not the outcome of hippocampal neuronal death, as no neuronal loss or dying hippocampal neurons were detected following chronic HU210 injection. A significant increase was observed in the hipoppocampal newborn neurons of mice following twice-daily HU210 injection for 10 days.

It has been shown that acute, high doses of cannabinoids produce anxiety-like effects in rats and depression-like effects in mice. But chronic administration of high, but not low, doses of HU210 exerts anxiolytic- and antidepressant-like effects. This suggests that cannabinoids are the only illicit drug that can promote adult hippocampal neurogenesis following chronic administration. This increase in hippocampal neurogenesis underlies the mechanism of anxiolytic- and andtidepressant-like effects produced by a high dose chronic HU210 treatment.

Journal of Clinical Investigation -- Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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Rev.DOS

Someone should break this down for us Lamen...

What is Hippocampal Neurogenesis? Good/Bad?


I liked that part.. Am I correct in my understanding in that the statement says if I smoke more instead of less I will have less anxiety, and depression?

Because I always have more anxiety and more depression when I don't have enough to smoke. So that makes sense to me?....

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kingseven

Someone ought to sponsor a smoke study for me! Monitor how I roll a blunt, smoke it, stare at the tube, get the munches, and forget all the bullshit! Then repeat! lol

squirrel_master

from Wiki:

"Neurogenesis (birth of neurons) is the process by which neurons are created. Most active during pre-natal development, neurogenesis is responsible for populating the growing brain."

so it's good.

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Freakshow68

in a nutshell, they are saying that cannibis use stimulates the body to rebuild and/or generate neurons in the brain.

Hippocampus - Wikipedia, the free encyclopedia

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You cannot strengthen the weak by weakening the strong.
You cannot bring about prosperity by discouraging thrift.
You cannot lift the wage earner up by pulling the wage payer down.
You cannot further the brotherhood of man by inciting class hatred.
You cannot build character and courage by taking away people's initiative
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Lou Cypher

Rev, that's what it means, but I think you already have that covered.

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Freakshow68

i have a very good friend that is completely off of her psych meds because she smokes weed. she has depression and anxiety. however, when she stops smoking for a few weeks, she feels like she needs those meds again. So I'm skeptical about this "discovery"

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You cannot help the poor by destroying the rich.
You cannot strengthen the weak by weakening the strong.
You cannot bring about prosperity by discouraging thrift.
You cannot lift the wage earner up by pulling the wage payer down.
You cannot further the brotherhood of man by inciting class hatred.
You cannot build character and courage by taking away people's initiative
and independence.
You cannot help people permanently by doing for them, what they
could and should do for themselves. - William J. H. Boetcker

kawliga

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I just cannot fathom that Marijuana, with all its history and medicinal properties, is illegal almost everywhere and yet alcohol, which has no redeeming qualities, is sold directly by the Government....shows the reality of our world doesn't it?

mayan

I'll take it...I would like all the neurons I can get. Particularly the hippocampal ones. Yum!

Still, in traveling around -say- Vancouver or Nelson, BC, I'd have to say that I saw quite a few people who looked like they had burnt out quite a few neurons.

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speedracer-x

That's when I'd start wondering how much pesticides and other spray additives/applications affect the smoke and therefore our neurons (more specifically when bought off the street since that's what the majority of people do).

HOMEGROWN FTW!