merurial

This study published in 2006 is of interest to me. I have a few questions for all of you on the topic of CBD.

Brazilian Journal of Medical Review and Biological Research:
Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug(2006)

Do you think that indica or sativa plants have higher amounts of CBD?
Do you think that CBD is part of the "high"?
Do you know of any strains that have larger percentages of CBD?

I would like to understand the CBD aspect a little more, so anyone who has info it'd be appreciated.

thanks everyone

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Goddess

That is an interesting study; thanks for linking it.

Since this and other studies have demonstrated CBD to have anxiolytic, antipsychotic and analgesic effects I do think it’s part of the high. I think many other cannabinoids probably are too, and the different percentages of them in different strains the reason the highs are different. Besides THC and CBD, 64 others have been identified and most of what I’ve read about Marinol indicates its influence is quite different from any marijuana high. It would be nice to be able to get or make pure CBD to try. Since most people find an indica stone more mellow maybe those strains have more CBD, but with so many other compounds involved who knows. It would also be nice to be able to easily test our for percentages of various cannabinoids. Someday.

Marinol vs. Natural Cannabis - NORML

edman2424

marinol is disappointing at best. tried it and cant say id ever attempt getting it again. i know it may have other uses but in my pharmacy its prescribed for those with eating disorders for various reasons. its supposed to induce the "munchies" and thats about all it does.....

i would definitely like to know more about the effects of thc vs cbd vs cbn though

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penguin

A CHEMOTAXONOMIC ANALYSIS OF CANNABINOID VARIATION IN CANNABIS (CANNABACEAE)
The classification system used recognizes three distinct chemotypes:
chemotype I high THC,low CBD
chemotype II comparable levels
chemotype III low THC, high CBD

Hilling and Mahlberg are suggesting that a single gene with two co-dominant alleles determines the THC/CBD ratio (chemotype), by determining the relative rates of conversion from CBG to either CBD or THC. The Bd allele produces more CBD ath the Bt allele produces more THC. Other alleles may be present in wild-type populations.

Marijuana breeding programs focus on chemotype I. In the view of Hillig & Mahlberg, this is a single species, Cannabis indica that comprises four "biotypes": narrow-leaf drug (NLD), wide-leaf drug (WLD), hemp, and feral (rudaral). In this system of classification, NLD corresponds to what seed banks call "pure sativa" and WLD corresponds to what seed banks call "pure indica".

This chart shows the frequency of the Bt allele in the populations they studied. The frequency of the Bd allele is presumed to be complementary to the frequency of Bt.

Among varieties available from the seed banks, "pure indica" can be expected to have the highest concentration of CBD. Narrow-leaf drug biotypes (what the seed banks call pure sativa) have the lowest concentration of CBD.

Dutch Passion lists the amount of THC for many of it's products, I am pretty sure that I remember seeing THC and CBD numbers from one of the seed banks but I don't recall which one. I also don't know how reliable those numbers are.

If you are looking for chemotype III, you're not likely to find it at the seed banks, although some of the plants described as pure indicas or having a "ruderalis" background will be heterozygous BtBd, and can be used to breed homozygous BdBd (= chemotype III = low THC, high CBD) lines. European hemp varieties are predominantly chemotype III, but have been bred aggressively to produce low levels of cannabinoids overall.

CBD doesn't by itself get you high, but is believed to modify the effects of THC, the paper linked in the first post says it reduces the anxiety caused by THC.

CBN is sedative. THC comverts to CBN. This happens at the amber trichome stage in living plants, and occurs during storage of harvested bud, where conversion rate depends on the amount of O2, heat, and light available (more of any = faster conversion).

There is little information about the psychoactive or physiological effects of the other 63 (or so) cannabinoids. I agree with Godess that differing cannabinoid profiles (beyond just CBD, THC, and CBN) are responsible for the different psychoactive and physiological effects of different varieties.

Thread moved to Medicinal Usage.


penguin

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Goddess

Thanks, Penguin, also an interesting study and observations.

It seems unlikely to me that BtBd plants could be obtained from seed banks since like you wrote, breeding programs focus on the homozygous BtBt chemotype, heterozygotes bred to each other would produce about 25% BdBd with low THC and so would have been eliminated from the breeding stock. It seems like their 25% BtBt descendants would quickly be favored.

CBD alone doesn’t produce a noticeable “high” typical of but clearly seems to have some mind-altering effects on its own since the first study linked in this thread indicates that it not only reduces THC-induced anxiety but also symptoms in schizophrenic and bipolar people without any THC.

It’d be nice to be able to obtain pure CBD since I have problems with anxiety, which probably has something to do with my preference for indica over sativa. I’d probably hate a strain with very high THC and low CBD, or Marinol. That first study mentions people ending up in a psychiatric hospital after consuming virtually devoid of CBD and I think they were just “regular” people, without preexisting anxiety issues. At least I always have diazepam available to keep me out of the hospital but would rather medicate with alone. Since hemp has been bred to produce low overall cannabinoid levels it doesn’t seem that crossing drug strains with it in an effort to get high CBD would be worthwhile.

penguin

Bd was present in the accessions assigned to the WLD biotype, which are from the University of Mississippi germplasm repository; this includes commercially available cultivars. Landraces from the hash-producing regions can be expected to have a reliably higher frequency of the Bd allele. If the allele is present in the breeding pool, then it will be possible to produce homozygous Bd individuals, as a fairly straightforward breeding project.

An alternative that may be of interest: Sativex


penguin

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Goddess

Thanks. Yeah, I read about the BtBd accessions from the WLD plants, but kind of got the idea they were talking about varieties used more for hash rather than smoke/ingestion. It seems like if a breeder bred very many generations they would get tired of 25% BdBd plants resulting from BtBd/BtBd crosses and those parents would be eliminated from the breeding stock before long.

Sativex sounds very interesting. I’ll try to find a way to obtain some.